A Silent Threat

11/21/2024

Early detection is key to saving lives in pancreatic cancer cases Area Gastroenterologist says risk factors for deadly disease include age, family history

Hidden in plain sight, pancreatic cancer can go undetected for months, revealing itself only after it has dangerously grown or spread to other organs.

Diagnosed in more than 66,000 U.S. patients each year, pancreatic cancer often does not cause any signs or symptoms. An estimated 51,750 people will die of the disease this year, according to the American Cancer Society.

November is National Pancreatic Cancer Awareness Month, and one of the best defenses against this deadly disease is early detection, says Anish Chopra, M.D., a gastroenterologist with Northwest Medical Group.

“Pancreatic cancer is often silent in its early stages, making early detection crucial to improving survival rates,” Dr. Chopra said. “By the time symptoms appear, the disease has often advanced, which is why awareness of the disease and getting diagnosed as quickly as possible are critical.”

Symptoms of pancreatic cancer include:

• Belly or back pain
• Enlargement of gallbladder or liver
• Fatigue or abnormal physical weakness
• Itchy skin (can be caused by jaundice)
• Jaundice (yellowing of the skin and in the whites of the eyes)
• Large, light-colored, greasy stools
• Loss of appetite
• Nausea and vomiting
• Pain or swelling in arm or leg (could be caused by blood clot)
• Sudden onset of Type 2 diabetes
• Weight loss

Treatment often depends on the type and stage of cancer, though interventions include surgery, radiation therapy, chemotherapy, targeted therapy and immunotherapy.

“While we don’t know what causes pancreatic cancer, there are factors that can put patients at a higher risk, including tobacco use, obesity, Type 2 diabetes and heavy exposure to cancer-causing carcinogens,” Dr. Chopra said. “These are all risk factors that patients can influence through lifestyle choices and preventive care.”

Other risk factors include age, sex, race and family history. As people age, their risk for pancreatic cancer also rises, with nearly all diagnoses occurring in people older than 45. Men and African-Americans are slightly more likely to develop pancreatic cancer.

“Research shows inherited gene mutations can cause as many as 10% of pancreatic cancers,” Dr. Chopra said. “Genetic syndromes that may cause this disease include hereditary breast and ovarian cancers, familial atypical multiple mole melanoma (FAMMM) syndrome, hereditary pancreatitis and other genes with defects passed from parents to their children.”

While there are no screening tests that have been shown to lower a person’s risk of dying from pancreatic cancer, genetic testing may help determine whether a person is at increased risk.

“It’s important to talk to your doctor about your individual risk of developing pancreatic cancer and any steps you should take to reduce your risk,” Dr. Chopra said. “It’s also critical if someone is experiencing pancreatic cancer symptoms to seek medical attention immediately. Time is of the essence.”

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